Hva vma urine test

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Hva vma urine test

First preferred test for screening for catecholamine-secreting tumors in a random urine specimen when requesting both homovanillic acid and vanillylmandelic acid. In the past, this test has been used to screen for pheochromocytoma. However, vanillylmandelic acid VMA is not the analyte of choice to rule out a diagnosis of pheochromocytoma.

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Recommended tests for that purpose include:. All patients receiving L-dopa should be identified to the laboratory when vanillylmandelic acid VMA and homovanillic acid HVA tests are ordered. Bactrim may interfere with detection of the analyte. Patient Preparation: Administration of L-dopa may falsely increase homovanillic acid and vanillylmandelic acid results; it should be discontinued 24 hours prior to and during collection of specimen.

Elevated values of homovanillic acid HVAvanillylmandelic acid VMAand other catecholamine metabolites eg, dopamine may be suggestive of the presence of a catecholamine-secreting tumor eg, neuroblastoma, pheochromocytoma, or other neural crest tumors. HVA and VMA levels may also be useful in monitoring patients who have been treated as a result of the above-mentioned tumors. HVA levels may also be altered in disorders of catecholamine metabolism: monamine oxidase-A deficiency can cause decreased urinary HVA values, while a deficiency of dopamine beta-hydrolase the enzyme that converts dopamine to norepinephrine can cause elevated urinary HVA values.

Homovanillic acid HVA and vanillylmandelic acid VMA measurements in urine are used for screening children for catecholamine-secreting tumors such as neuroblastoma, pheochromocytoma, and other neural crest tumors and monitoring those who have had treatment for these tumors.

HVA measurement is also useful to diagnose children with disorders of catecholamine metabolism such as monoamine oxidase-A deficiency and dopamine beta-hydroxylase deficiency, which results in decreased or elevated urinary HVA values, respectively. VMA is not the analyte of choice for diagnosis of pheochromocytoma, which is better detected by testing for metanephrines.

Treatment with L-dopa can impact test results and should be discontinued 24 hours prior to collection. Bactrim can impact test results and should be noted at time of collection. If not ordering electronically, complete, print, and send an Oncology Test Request T with the specimen. Click here to view the Urine Aliquoting Guide for Processing.

All You Need to Know About a VMA Test

Specimen Type Urine. Advisory Information In the past, this test has been used to screen for pheochromocytoma. Patient's age is required. Specimen Required Patient Preparation: Administration of L-dopa may falsely increase homovanillic acid and vanillylmandelic acid results; it should be discontinued 24 hours prior to and during collection of specimen. Collect a random urine specimen.

Specimen Minimum Volume 2 mL. Day s and Time s Performed Monday through Friday; 8 a.

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Test Classification This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.

Food and Drug Administration. Clinical Information Elevated values of homovanillic acid HVAvanillylmandelic acid VMAand other catecholamine metabolites eg, dopamine may be suggestive of the presence of a catecholamine-secreting tumor eg, neuroblastoma, pheochromocytoma, or other neural crest tumors. Cautions No significant cautionary statements. Analytic Time 2 days not reported on Sunday. Highlights Homovanillic acid HVA and vanillylmandelic acid VMA measurements in urine are used for screening children for catecholamine-secreting tumors such as neuroblastoma, pheochromocytoma, and other neural crest tumors and monitoring those who have had treatment for these tumors.

Forms If not ordering electronically, complete, print, and send an Oncology Test Request T with the specimen. Website Feedback.Neuroblastomas are usually found when a child is brought to the doctor because of signs or symptoms he or she is having.

If a tumor is suspected, tests will be needed to confirm the diagnosis. If your child has signs or symptoms that might be caused by a neuroblastoma or another tumorthe doctor will ask about the symptoms and how long they have been present.

The doctor might also ask if there is any history of possible risk factorssuch as a family history of neuroblastoma. The doctor will examine your child for possible signs of a neuroblastoma and other health problems. For example, the doctor may be able to see or feel an abnormal mass or swelling.

The doctor might feel to see if the child has lumps or bumps under the skin and examine your child's eyes closely. They might also look at your child's blood pressure because sometimes neuroblastoma cells can make hormones that cause high blood pressure.

Some signs that could be caused by neuroblastoma, such as fever and enlarged lymph nodes, are much more likely to be caused by an infection, so the doctor might look for other signs of infection at first.

If the history and exam suggest a child might have a neuroblastoma or another type of tumormore tests will be done. These could include blood and urine tests, imaging tests, and biopsies. These tests are important because many of the symptoms and signs of neuroblastoma can also be caused by other diseases, such as infections, or even other types of cancer. The body makes many different types of hormones. Sympathetic nerve cells normally release hormones called catecholaminessuch as epinephrine adrenaline and norepinephrine, which enter the blood and eventually break down into smaller pieces, called metabolites.

The metabolites normally pass out of the body in urine. When epinephrine and norepinephrine are broken down by the body, the two most common metabolites made are:. Neuroblastoma cells can also make these catecholamines. These 2 catecholamine metabolites can be measured in blood and urine.

In most cases, neuroblastoma cells make enough catecholamines to be detected by blood or urine tests. If neuroblastoma cells are making catecholamines, the amount of HVA and VMA in urine or blood will be higher than expected.

A urinalysis urine test may also be done to further check kidney function. Imaging tests use x-rays, magnetic fields, sound waves, or radioactive substances to create pictures of the inside of the body.

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Imaging tests can be done for a number of reasons, including:. If neuroblastoma is highly suspected, the most common imaging test to have first is usually an MRI or CT scan. If your child is diagnosed with neuroblastoma, they will have an MIBG scan as well. Most children who have or might have neuroblastoma will have one or more of these tests, but might not need all of these tests.

Children with neuroblastoma are often very young, so it can be hard to do some of these tests because the child might need to hold very still.Urine catecholamine metabolites, particulary homovanillate HVA and vanillylmandelic acid VMAis most useful in the diagnosis and follow-up of catecholamine secreting tumours of the sympathetic nervous system.

These include neuroblastoma, ganglioneuroma and phaeochromocytoma.

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To request this test please send sample with a request providing patient ID three identifiersspecimen information, assay required, relevant clinical details and sender information. Before sending sample please read details on requesting and labelling by clicking on the link. Please also refer to any additional information provided for this test. The Chemical Pathology Laboratory provides an extensive range of services covering both routine biochemistry and specialised analysis and interpretation.

Our laboratory Our hospital. Description Urine catecholamine metabolites, particulary homovanillate HVA and vanillylmandelic acid VMAis most useful in the diagnosis and follow-up of catecholamine secreting tumours of the sympathetic nervous system.

Request a test To request this test please send sample with a request providing patient ID three identifiersspecimen information, assay required, relevant clinical details and sender information.

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Laboratory service Chemical Pathology Sample requirements 2ml fresh random urine in a plain universal container. Not required. Chemical Pathology The Chemical Pathology Laboratory provides an extensive range of services covering both routine biochemistry and specialised analysis and interpretation.While we are ranked among the best children's hospitals in the country, it's our compassionate approach to treatment that makes us truly exceptional.

Through a combination of revolutionary treatments and extraordinary patient experiences, our care does more than heal. It brings the entire family together for emotional support and understanding across multiple locations to reach you in the community where you live.

hva vma urine test

Search our Site. Need Help? Operator Ask Children's 8 a. M-F For Healthcare Professionals. Hower Medical Library Wellness Resources. Nursing Overview. Research Institute. Search our site:. Toggle navigation. Laboratory Services. Centralized Core Laboratory : Chemistry. Specimen Type:. Tube Type:. Collection Volume:.

Special Instructions:. Urine pH will be adjusted to between pH 1. Additional Info:. CPT Code:. View and print a requisition form for this test. View and print ONLY the info for this test. Close Print.Vanillylmandelic acid VMA is a chemical intermediate in the synthesis of artificial vanilla flavorings [1] and is an end-stage metabolite of the catecholamines dopamineepinephrineand norepinephrine.

It is produced via intermediary metabolites. VMA synthesis is the first step of a two-step process practiced by Rhodia since the s to synthesize artificial vanilla.

VMA is found in the urinealong with other catecholamine metabolites, including homovanillic acid HVAmetanephrineand normetanephrine. In timed urine tests the quantity excreted usually per 24 hours is assessed along with creatinine clearance, and the quantity of cortisolscatecholaminesand metanephrines excreted is also measured.

Urinary VMA is elevated in patients with tumors that secrete catecholamines. These urinalysis tests are used to diagnose an adrenal gland tumor called pheochromocytomaa tumor of catecholamine -secreting chromaffin cells. These tests may also be used to diagnose neuroblastomasand to monitor treatment of these conditions.

Norepinephrine is metabolised into normetanephrine and VMA. Norepinephrine is one of the hormones produced by the adrenal glandswhich are found on top of the kidneys. These hormones are released into the blood during times of physical or emotional stress, which are factors that may skew the results of the test.

From Wikipedia, the free encyclopedia.

hva vma urine test

CAS Number. Interactive image Interactive image. Beilstein Reference. PubChem CID. Chemical formula. Retrieved 19 December Rang; Maureen M.

Dale; Ritter, James M. Edinburgh: Churchill Livingstone. Neurotransmitter metabolic intermediates. Tumor markers. CD3 CD79a. Thyroglobulin Medullary thyroid cancer Calcitonin Carcinoembryonic antigen. Normetanephrine Enolase 2. Synaptophysin Chromogranin A. Homovanillic acid. Glial fibrillary acidic protein. S protein Melanoma inhibitory activity.

hva vma urine test

Carcinoembryonic antigen Enolase 2 Autocrine motility factor. Factor VIII. CA Carcinoembryonic antigen. Namespaces Article Talk.Definition: This is a test that measures the level of catecholamines or catecholamine metabolites break-down products in the urine. How the test is performed: For this test, you must urinate into a special bag or container every time you use the bathroom for hour period. Thoroughly wash the area around the urethra the hole where urine flows out.

Open a urine collection bag a plastic bag with an adhesive paper on one end.

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For males, place the entire penis in the bag and attach the adhesive to the skin. For females, place the bag over the two folds of skin on either side of the vagina labia. Put a diaper on the baby over the bag.

The infant should be checked frequently and the bag changed after the infant has urinated. Empty the urine from the bag into the container provided by your doctor. Because lively infants can cause the bag to move, this procedure may take a couple of attempts. Extra collection bags may be necessary.

How to prepare for the test: A health care provider will tell you whether or not to discontinue any drugs or activities that may interfere with the test. Certain foods can increase urinary catecholamines, including coffee, tea, bananas, chocolate, cocoa, citrus fruits, and vanilla. Avoid these for several days prior to the test. How the test will feel: The test involves only normal urination, and there is no discomfort.

Why the test is performed: The test is primarily used to diagnose pheochromocytoma and neuroblastoma, and to monitor the effectiveness of their treatments. Urine catecholamine levels are elevated in the majority of neuroblastoma cases. Catecholamines are small, chemically similar molecules derived from the amino acid tyrosine. The major catecholamines are dopamine, norepinephrine, and epinephrine old name: adrenalin. All of the catecholamines are broken down by their target tissues such as the brain or by the liver and become inactive substances that appear in the urine:.

What abnormal results mean: Elevated levels of urinary catecholamines may indicate:. Special considerations: The accuracy of the test can be affected by several foods and drugs as well as physical activity and stress See "How to prepare for the test". Toggle navigation.First preferred test for screening for catecholamine-secreting tumors in a random urine specimen when requesting both homovanillic acid and vanillylmandelic acid.

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In the past, this test has been used to screen for pheochromocytoma. However, vanillylmandelic acid VMA is not the analyte of choice to rule out a diagnosis of pheochromocytoma. Recommended tests for that purpose include:. All patients receiving L-dopa should be identified to the laboratory when vanillylmandelic acid VMA and homovanillic acid HVA tests are ordered. Bactrim may interfere with detection of the analyte.

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Patient Preparation: Administration of L-dopa may falsely increase homovanillic acid and vanillylmandelic acid results; it should be discontinued 24 hours prior to and during collection of specimen. Elevated values of homovanillic acid HVAvanillylmandelic acid VMAand other catecholamine metabolites eg, dopamine may be suggestive of the presence of a catecholamine-secreting tumor eg, neuroblastoma, pheochromocytoma, or other neural crest tumors.

HVA and VMA levels may also be useful in monitoring patients who have been treated as a result of the above-mentioned tumors. HVA levels may also be altered in disorders of catecholamine metabolism: monamine oxidase-A deficiency can cause decreased urinary HVA values, while a deficiency of dopamine beta-hydrolase the enzyme that converts dopamine to norepinephrine can cause elevated urinary HVA values. If not ordering electronically, complete, print, and send an Oncology Test Request T with the specimen.

Specimen Type Urine. Advisory Information In the past, this test has been used to screen for pheochromocytoma.

All You Need to Know About a VMA Test

Patient's age is required. Specimen Required Patient Preparation: Administration of L-dopa may falsely increase homovanillic acid and vanillylmandelic acid results; it should be discontinued 24 hours prior to and during collection of specimen.

Collect a random urine specimen. Specimen Minimum Volume 2 mL. Day s and Time s Performed Monday through Friday; 8 a. Test Classification This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U. Food and Drug Administration.

hva vma urine test

Clinical Information Elevated values of homovanillic acid HVAvanillylmandelic acid VMAand other catecholamine metabolites eg, dopamine may be suggestive of the presence of a catecholamine-secreting tumor eg, neuroblastoma, pheochromocytoma, or other neural crest tumors. Analytic Time 2 days not reported on Sunday.

NY State Approved Yes. Forms If not ordering electronically, complete, print, and send an Oncology Test Request T with the specimen.

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